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Prostate health care dietary supplements produced with organic lycopene, the perfect antioxidant for prostate protection. An stronger organic antioxidant action preventing prostate diseases as inflammation, prostate cancer and others.

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Prostate Dietary Supplements as Italian manufacturer industry we offer to the prostate care distributors and medical dietary industry a range of powerful "Organic Dietary Supplements" produced, according to the diet health international standards, with made in Italy organic lycopene perfect organic antioxidant.

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ITALIAN HEALTH DIET FOOD SUPPLEMENTS MANUFACTURER FOR PHARMACY DISTRIBUTORS

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PROSTATE CANCER SCIENTIFIC RESEARCHES ABOUT HEALTH PROSTATE CARE DIETARY SUPPLEMENT There are many worldwide researches defining the high power of the organic components for human health care supplements manufacturing industry. Scientific pubblications from University in Japan, USA, Italy, Australia,... confirms the quality and efficience of the Organic Lycopene to avoid main human diseases as prostate cancer, Parkinson, Alzheimer disease and other type of cancer. The scientific staff of Pierre Italy has used all of them as scientific reference to improve, to define our organic dietary supplements... APPLY FOR DISTRIBUTION

HEALTH PROSTATE+® THE ORGANIC PROSTATE CANCER PREVENTION SUPPLEMENT - TECHNICAL INFORMATION

SCIENTIFIC RESEARCH ABOUT PROSTATE CANCER AND OTHER TYPES OF CANCER PREVENTION SYSTEMS

Ansari M, Ansari S. Sanjay Gandhi Postgraduate Institute of Medical Sciences, Department of Urology and Renal transplantation, Rae Breli Road, Lucknow-UP (226014), India. ansarimsa@hotmail.com , Sanjay Gandhi Postgraduate Institute of Medical Sciences, Department of Urology and Renal transplantation, Rae Breli Road, Lucknow-UP (226014), India. Lycopene and prostate cancer. Future Oncol. 2005 Jun;1(3):425-430

Stacewicz-Sapuntzakis M, Bowen PE. Department of Human Nutrition, University of Illinois at Chicago, 1919 West Taylor St. Chicago, IL 60612, USA. Role of lycopene and tomato products in prostate health. Biochim Biophys Acta. 2005 May 30;1740(2):202-5. Epub 2005 Mar 13

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Siler U, Herzog A, Spitzer V, Seifert N, Denelavas A, Hunziker PB, Barella L, Hunziker W, Lein M, Goralczyk R, Wertz K. - DSM Nutritional Products Ltd., Human Nutrition and Health, Basel, Switzerlandand. Lycopene effects on rat normal prostate and prostate tumor tissue. J Nutr. 2005 Aug;135(8):2050S-2S

Kaplan SA - Lycopene: modes of action to promote prostate health. J Urol. 2005 Aug;174(2):679; discussion 679.

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Mohanty NK, Saxena S, Singh UP, Goyal NK, Arora RP. Department of Urology, V.M. Medical College & Safdarjang Hospital, New Delhi, India. Lycopene as a chemopreventive agent in the treatment of high-grade prostate intraepithelial neoplasia. Urol Oncol. 2005 Nov-Dec;23(6):383-5

Guns ES, Cowell SP. - Department of Surgery, University of British Columbia, Canada. eguns@vanhosp.bc.ca Drug Insight: lycopene in the prevention and treatment of prostate cancer. Nat Clin Pract Urol. 2005 Jan;2(1):38-43.

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Fraser ML, Lee AH, Binns CW. Curtin University of Technology, School of Public Health, GPO Box U 1987, Perth WA 6845, Australia. nugget008@hotmail.com Lycopene and prostate cancer: emerging evidence Expert Rev Anticancer Ther. 2005 Oct;5(5):847-54

Kirsh VA, Mayne ST, Peters U, Chatterjee N, Leitzmann MF, Dixon LB, Urban DA, Crawford ED, Hayes RB. Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, MD 20892, USA. A prospective study of lycopene and tomato product intake and risk of prostate cancer. Cancer Epidemiol Biomarkers Prev. 2006 Jan;15(1):92-8

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Everson KM, McQueen CE. Drug Information Center, University of Missouri-Kansas City, 64108, USA. Lycopene for prevention and treatment of prostate cancer. Am J Health Syst Pharm. 2004 Aug 1;61(15):1562-6

Barber NJ, Barber J. Department of Urology, St George's Hospital, London, UK.Lycopene and prostate cancer. Prostate Cancer Prostatic Dis. 2002 Mar;5(1):6-12. PROSTATE CANCER AND PROSTATIC DISEASES: (2002) 5, 6-12. DOI: 10.1038/sj/pcan/4500560

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Barber NJ, Barber J. Department of Urology, St George's Hospital, London, UK.Lycopene and prostate cancer. Prostate Cancer Prostatic Dis. 2002 Mar;5(1):6-12. PROSTATE CANCER AND PROSTATIC DISEASES: (2002) 5, 6-12. DOI: 10.1038/sj/pcan/4500560

Bowen PE - Department of Human Nutrition, University of Illinois at Chicago, Chicago, IL 60612. Selection of surrogate endpoint biomarkers to evaluate the efficacy of lycopene/tomatoes for the prevention/progression of prostate cancer. J Nutr. 2005 Aug;135(8):2068S-70S

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Gann PH - Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.Intermediate biomarkers of lycopene/tomato effects in high-risk prostatic tissue. J Nutr. 2005 Aug;135(8):2065S-7S

Tang L, Jin T, Zeng X, Wang JS. - Department of Environmental Toxicology and The Institute of Environmental and Human Health, Texas Tech University System, Lubbock, TX; Lycopene inhibits the growth of human androgen-independent prostate cancer cells in vitro and in BALB/c nude mice. J Nutr. 2005 Feb;135(2):287-90.

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Chan JM, Gann PH, Giovannucci EL. Department of Epidemiology and Biostatistics, 1600 Divisadero St, Box 1695, San - Francisco, CA 94143-1695, USA. june@uorg.ucsf.edu Role of diet in prostate cancer development and progression. J Clin Oncol. 2005 Nov 10;23(32):8152-60

Ansari MS, Gupta NP - Department of Urology, All India Institute of Medical Sciences, New Delhi 110029, India. ansarimsa@hotmail.com Lycopene: a novel drug therapy in hormone refractory metastatic prostate cancer. Urol Oncol. 2004 Sep-Oct;22(5):415-20

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Obermuller-Jevic UC,Olano-Martin E, Corbacho AM, Eiserich JP,van der Vliet A, Valacchi G, Cross CE, Packer L Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of California, Davis, CA 95616, USA. Lycopene inhibits the growth of normal human prostate epithelial cells in vitro. J Nutr. 2003 Nov;133(11):3356-60.

Hwang ES, Bowen PE. - Department of Human Nutrition, University of Illinois, Chicago, IL 61801, USA. Effects of tomato paste extracts on cell proliferation, cell-cycle arrest and apoptosis in LNCaP human prostate cancer cells. Biofactors. 2005;23(2):75-84.

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Chang S, Erdman JW Jr, Clinton SK, Vadiveloo M, Strom SS, Yamamura Y, Duphorne CM, Spitz MR, Amos CI, Contois JH, Gu X, Babaian RJ, Scardino PT, Hursting SD. Relationship between plasma carotenoids and prostate cancer. Nutr Cancer. 2005;53(2):127-34

Kristal AR, Schenk JM. - Fred Hutchinson Cancer Research Center, Seattle, WA 98109-4686. Directions for future epidemiological research in lycopene and prostate cancer risk. J Nutr. 2005 Aug;135(8):2037S-9S

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Giovannucci E. - Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115 and Departments of Nutrition and Epidemiology, Harvard School of Public Health, Boston, MA 02115. Tomato Products, Lycopene, and Prostate Cancer: A Review of the Epidemiological Literature. J Nutr. 2005 Aug;135(8):2030S-2031S

Giovannucci E, Clinton SK - Harvard Medical School, Channing Laboratory, Boston, Massachusetts 02115, USA. Tomatoes, lycopene, and prostate cancer. Proc Soc Exp Biol Med 1998 Jun;218(2):129-139

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Giovannucci E, Ascherio A, Rimm EB, Stampfer MJ, Colditz GA, Willett WC Channing Laboratory, Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.Intake of carotenoids and retinol in relation to risk of prostate cancer. J Natl Cancer Inst 1995 Dec 6;87(23):1767-1776

Pastori M, Pfander H, Boscoboinik D, Azzi A Institute for Biochemistry and Molecular Biology, University of Bern, Bern, CH-3012, Switzerland. Lycopene in association with alpha-tocopherol inhibits at physiological concentrations proliferation of prostate carcinoma cells. Biochem Biophys Res Commun 1998 Sep 29;250(3):582-5

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Gann PH, Ma J, Giovannucci E, Willett W, Sacks FM, Hennekens CH, Stampfer MJ Department of Preventive Medicine, Northwestern University Medical School, Chicago, Illinois 60611, USA. pgann@nwu.edu Lower prostate cancer risk in men with elevated plasma lycopene levels: results of a prospective analysis. Cancer Res 1999 Mar 15;59(6):1225-30

Rao AV, Fleshner N, Agarwal S - Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, ON, Canada. v.rao@utoronto.ca “Serum and tissue lycopene and biomarkers of oxidation in prostate cancer patients: a case-control study”. Nutr Cancer 1999;33(2):159-64

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Norrish AE, Jackson RT, Sharpe SJ, Skeaff CM - Department of Community Health, University of Auckland, New Zealand. Prostate cancer and dietary carotenoids. Am J Epidemiol 2000 Jan 15;151(2):119-23

Lu QY, Hung JC, Heber D, Go VL, Reuter VE, Cordon-Cardo C, Scher HI, Marshall JR, Zhang ZF. Center for Human Nutrition, University of California at Los Angeles School of Medicine, Los Angeles, CA 90095, USA. qlu@mednet.ucla.edu Inverse associations between plasma lycopene and other carotenoids and prostate cancer. Cancer Epidemiol Biomarkers Prev 2001 Jul;10(7):749-56

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Matlaga BR, Hall MC, Stindt D, Torti FM. Department of Urology and Comprehensive Cancer Center, Wake Forest University School of Medicine, Winston-Salem, North Carolina.Response of hormone refractory prostate cancer to lycopene. J Urol 2001 Aug;166(2):613

Bowen, P. E. University of Illinois, Chicago, IL, 60612: pbowen@uic.edu, USA Tomato sauce supplementation reduces DNA damage in men with prostate cancer. Abstracts of Papers American Chemical Society VOL. 222 NO. 1-2,2001 PP. AGFD129. American Chemical Society CONFERENCE DATE August 26-30, 2001 CONFERENCE TITLE: 222nd National Meeting of the American Chemical Society

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Van Breemen RB. Department of Medicinal Chemistry and Pharmacognosy, University of Illinois College of Pharmacy, Chicago, IL 60612. How do intermediate endpoint markers respond to lycopene in men with prostate cancer or benign prostate hyperplasia? J Nutr. 2005 Aug;135(8):2062S-4S

Matos HR, Marques SA, Gomes OF, Silva AA, Heimann JC, Di Mascio P, Medeiros MH. Departamento de Fisiologia, Universidade Federal de Sergipe, Sao Cristovao, SE, Brasil.Lycopene and ss-carotene protect in vivo iron-induced oxidative stress damage in rat prostate. Braz J Med Biol Res. 2006 Feb;39(2):203-10. Epub 2006 Feb 2

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Lowe JF, Frazee LA. - Department of Pharmacy, Akron General Medical Center, Akron, Ohio. Update on prostate cancer chemoprevention. Pharmacotherapy. 2006 Mar;26(3):353-9

Wisard M, Leisinger HJ. Service d'urologie CHUV, Lausanne. [Prostate cancer prevention] - Rev Med Suisse. 2006 Jan 11;2(48):163-5

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Limpens J, Schroder FH, de Ridder CM, Bolder CA, Wildhagen MF, Obermuller-Jevic UC, Kramer K, van Weerden WM. Department of Urology, Erasmus MC, Rotterdam, The Netherlands. Combined lycopene and vitamin E treatment suppresses the growth of PC-346C human prostate cancer cells in nude mice. J Nutr. 2006 May;136(5):1287-93.

Neill MG, Fleshner NE. Division of UroOncology, University Health Network, Toronto, Ontario, Canada. An update on chemoprevention strategies in prostate cancer for 2006. Curr Opin Urol. 2006 May;16(3):132-7

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Clark PE, Hall MC, Borden LS Jr, Miller AA, Hu JJ, Lee WR, Stindt D, D'Agostino R Jr, Lovato J, Harmon M, Torti FM. Department of Urology and Comprehensive Cancer Center, Wake Forest University Health Sciences, Winston-Salem, North Carolina 27157, USA. peclark@wfubmc.edu Phase I-II prospective dose-escalating trial of lycopene in patients with biochemical relapse of prostate cancer after definitive local therapy.Urology. 2006 Jun;67(6):1257-61

Rossinow JK, Balajee AS, Gewanter RM, Ennis RD, Schiff PB, Katz AE, Geard CR. Albert Einstein College of Medicine, Bronx, NY, USA - Effects of lycopene and vitamin E on gamma-irradiated prostate cancer cells. Int J Radiat Oncol Biol Phys. 2003 Oct 1;57(2 Suppl):S348-9

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Segev Y, Nativ O-Urology Department, The Bnei Zion Medical Center, Haifa. segevyakir@yahoo.com Nutrition and pharmacological treatment for prevention of prostate cancer. Harefuah. 2006 Jan;145(1):47-51, 76-7

Campbell JK, Rogers RB, Lila MA, Erdman JW Jr. Division of Nutritional Sciences, University of Illinois at Urbana-Champaign, 905 South Goodwin Avenue, and Department of Natural Resources and Environmental Sciences, University of Illinois at Urbana-Champaign, 1201 South Dorner Drive, Urbana, Illinois 61801. Biosynthesis of (14)C-Phytoene fromTomato Cell Suspension Cultures (Lycopersicon esculentum) for Utilization in Prostate Cancer Cell Culture Studies. J Agric Food Chem. 2006 Feb 8;54(3):747-755

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Tavani A, Longoni E, Bosetti C, Maso LD, Polesel J, Montella M, Ramazzotti V, Negri E, Franceschi S, Vecchia CL. - Istituto di Ricerche Farmacologiche "Mario Negri", Milan, Italy.Intake of Selected Micronutrients and the Risk of Surgically Treated Benign Prostatic Hyperplasia: A Case-Control Study from Italy. Eur Urol. 2005 Dec 28

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Schroder FH, Roobol MJ, Boeve ER, de Mutsert R, Zuijdgeest-van Leeuwen SD, Kersten I, Wildhagen MF, van Helvoort A. Department of Urology, Erasmus MC Rotterdam, The Netherlands. Randomized, Double-Blind, Placebo-Controlled Crossover Study in Men with Prostate Cancer and Rising PSA: Effectiveness of a Dietary Supplement.Eur Urol. 2005 Dec;48(6):922-31. Epub 2005 Oct 17

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Sonn GA, Aronson W, Litwin MS. Department of Urology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA [2] 2Department of Health Services, UCLA School of Public Health, Los Angeles, California, USA [3] 3UCLA Jonsson Comprehensive Cancer Center, Los Angeles, California, USA. Impact of diet on prostate cancer: a review. Prostate Cancer Prostatic Dis. 2005 Aug 30; Prostate Cancer and Prostatic Diseases advance online publication, 30 August 2005; doi:10.1038/sj.pcan.4500825

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Almushatat AS, Talwar D, McArdle PA, Williamson C, Sattar N, O'reilly DS, Underwood MA, McMillan DC. University Department of Surgery, Royal Infirmary, Glasgow, UK. Vitamin antioxidants, lipid peroxidation and the systemic inflammatory response in patients with prostate cancer. Int J Cancer. 2005 Aug 16; 2005 Wiley-Liss, Inc

Clinton SK. Molecular Carcinogenesis and Chemoprevention Program, The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210. Tomatoes or lycopene: a role in prostate carcinogenesis? J Nutr. 2005 Aug;135(8):2057S-9S

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Tappel A. Department of Food Science and Technology, University of California, Davis, CA 95616, USA. Lysosomal and prostasomal hydrolytic enzymes and redox processes and initiation of prostate cancer. Med Hypotheses. 2005;64(6):1170-2.

Iwasaki M, Tsugane S. - Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center. Risk factors and current chemoprevention studies for prostate cancer - Nippon Rinsho. 2005 Feb;63(2):321-6

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Ansari MS, Sgupta NP. Bratt O. A comparison of lycopene and orchidectomy vs orchidectomy alone in the management of advanced prostate cancer. BJU Int. 2005 Feb; 95(3):453 . BJU Int. 2005 Jan; 95(1):192. Comment on: BJU Int. 2003 Sep;92(4):375-8; discussion 378

Comhaire F, Mahmoud A. Ghent University Hospital, Gent, Belgium. Preventing diseases of the prostate in the elderly using hormones and nutriceuticals. Aging Male. 2004 Jun;7(2):155-69

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Srivastava AR, Dalela D. - King George's Medical University, Lucknow, Uttar Pradesh, India. Prostate cancer: altering the natural history by dietary changes.
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Jian L, Du CJ, Lee AH, Binns CW. - School of Public Health, Curtin University of Technology, Perth, Australia. Do dietary lycopene and other carotenoids protect against prostate cancer? Int J Cancer. 2004 Oct 28. (c) 2004 Wiley-Liss, Inc.

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Hwang ES, Bowen PE. - Department of Human Nutrition, University of Illinois, Chicago, Illinois, U.S.A. Cell Cycle Arrest and Induction of Apoptosis by Lycopene in LNCaP Human Prostate Cancer Cells. J Med Food. 2004 Fall;7(3):284-9

Bosetti C, Talamini R, Montella M, Negri E, Conti E, Franceschi S, La Vecchia C. Istituto di Ricerche Farmacologiche "Mario Negri," Milan, Italy. Retinol, carotenoids and the risk of prostate cancer: A case-control study from Italy. Int J Cancer. 2004 Nov 20;112(4):689 - Copyright 2004 Wiley-Liss, Inc

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Sanderson M, Coker AL, Logan P, Zheng W, Fadden MK. University of Texas-Houston School of Public Health at Brownsville, 80 Fort Brown, Brownsville, TX 78520; USA. Ph.: 956-554-5162 fax: 956-554-5152, e-mail: msanderson@utb.edu - Lifestyle and prostate cancer among older african-american and caucasian men in South Carolina. Cancer Causes Control. 2004 Sep;15(7):647-55

Dagnelie PC, Schuurman AG, Goldbohm RA, Van den Brandt PA. Department of Epidemiology, Maastricht University, Maastricht, The Netherlands. Dagnelie@epid.unimaas.nl Diet, anthropometric measures and prostate cancer risk: a review of prospective cohort and intervention studies. BJU Int. 2004 May;93(8):1139-50

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Siler U, Barella L, Spitzer V, Schnorr J, Lein M, Goralczyk R, Wertz K. Lycopene and Vitamin E interfere with autocrine/paracrine loops in the Dunning prostate cancer model. FASEB J. 2004 Apr 14

Klein EA, Thompson IM. Section of Urologic Oncology, Glickman Urological Institute, Cleveland Clinic Foundation, Cleveland, Ohio and Department of Urology, University of Texas Health Sciences Center, San Antonio, Texas, USA. Update on chemoprevention of prostate cancer. Curr Opin Urol. 2004 May;14(3):143-149

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Limpens J, van Weerden WM, Kramer K, Pallapies D, Obermuller-Jevic UC, Schroder FH.Re: Prostate carcinogenesis in N-methyl-N-nitrosourea (NMU)-testosterone-treated rats fed tomato powder, lycopene, or energy-restricted diets. J Natl Cancer Inst. 2004 Apr 7;96(7):554; author reply 554-5. Comment on: J Natl Cancer Inst. 2003 Nov 5;95(21):1578-86

Kristal AR - Cancer Prevention Program, Fred Hutchinson Cancer Research Program, Seattle, Washington 98109-1024, USA. akristal@fhcrc.org Vitamin A, retinoids and carotenoids as chemopreventive agents for prostate cancer. J Urol. 2004 Feb;171(2 Pt 2):S54-8; discussion S58

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Willis MS, Wians FH - Department of Pathology, The University of Texas Southwestern Medical Center, Dallas, TX, USA - The role of nutrition in preventing prostate cancer: a review of the proposed mechanism of action of various dietary substances. Clin Chim Acta 2003 Apr;330(1-2):57-83

Wu K, Erdman JW Jr, Schwartz SJ, Platz EA, Leitzmann M, Clinton SK, DeGroff V, Willett WC, Giovannucci E. Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA. kana.wu@channing.harvard.edu - Plasma and dietary carotenoids, and the risk of prostate cancer: a nested case-control study. Cancer Epidemiol Biomarkers Prev. 2004 Feb;13(2):260-9

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Kim HS, Bowen P, Chen L, Duncan C, Ghosh L, Sharifi R, Christov K. Department of Human Nutrition, University of Illinois at Chicago, 1919 W. Taylor, Chicago, IL 60612, USA.Effects of tomato sauce consumption on apoptotic cell death in prostate benign hyperplasia and carcinoma. Nutr Cancer. 2003;47(1):40-7

Forbes K, Gillette K, Sehgal I. - Center for Protease Research, North Dakota State University, Fargo, North Dakota 58105, USA. Lycopene increases urokinase receptor and fails to inhibit growth or connexin expression in a metastatically passaged prostate cancer cell line: a brief communication. Exp Biol Med (Maywood). 2003 Sep;228(8):967-71

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Boileau TW, Liao Z, Kim S, Lemeshow S, Erdman JW Jr, Clinton SK. Division of Nutritional Sciences, University of Illinois, Urbana-Champaign, IL (TWMB, JWE). J Natl Cancer Inst. 2003 Nov 5;95(21):1578-86. Prostate carcinogenesis in N-methyl-N-nitrosourea (NMU)-testosterone-treated rats fed tomato powder, lycopene, or energy-restricted diets

Pohar KS, Gong MC, Bahnson R, Miller EC, Clinton SK. Division of Urology, Department of Surgery, Ohio State University College of Medicine and Public Health, 4841 UHC, 456 West 10th Avenue, OH 43210, Columbus, USA, pohar-1@medctr.osu.edu Tomatoes, lycopene and prostate cancer: a clinician's guide for counseling those at risk for prostate cancer. World J Urol. 2003 May;21(1):9-14. Epub 2003 Mar 22

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Pathak SK, Sharma RA, Mellon JK - Cancer Biomarkers and Prevention Group, Department of Oncology, University of Leicester, Leicester, LE2 7LX, UK.Chemoprevention of prostate cancer by diet-derived antioxidant agents and hormonal manipulation (Review). Int J Oncol 2003 Jan;22(1):5-13

Huang HY, Alberg AJ, Norkus EP, Hoffman SC, Comstock GW, Helzlsouer KJ. Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD. Prospective study of antioxidant micronutrients in the blood and the risk of developing prostate cancer. Am J Epidemiol 2003 Feb 15;157(4):335-44

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Boyle P, Severi G, Giles GG. Division of Epidemiology and Biostatistics, European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy. director.epi@ieo.it The epidemiology of prostate cancer. Urol Clin North Am. 2003 May;30(2):209-17

Richards LR, Benghuzzi H, Tucci M, Hughes J. Clinical Health Sciences Graduate Program, School of Health Related Professions, Department of Pathology and Orthopedic Surgery and Rehab University of Mississippi Medical Center, Jackson, Mississippi, USA. The synergistic effect of conventional and sustained delivery of antioxidants on LNCaP prostate cancer cell line. Biomed Sci Instrum. 2003;39:402-7

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Ansari MS, Gupta NP. Department of Urology, All India Institute of Medical Science, New Delhi, India. A comparison of lycopene and orchidectomy vs orchidectomy alone in the management of advanced prostate cancer. BJU Int. 2003 Sep;92(4):375-8

Gann PH, Khachik F - Tomatoes or lycopene versus prostate cancer: is evolution anti-reductionist? J Natl Cancer Inst. 2003 Nov 5;95(21):1563-5

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Miano L. - Clinica Urologica, II Facolta di Medicina e Chirurgia, Universita di Roma La Sapienza, Rome, Italy. Mediterranean diet, micronutrients and prostate carcinoma: a rationale approach to primary prevention of prostate cancer. Arch Ital Urol Androl. 2003 Sep; 75(3): 166-78

Crawford ED. Section of Urologic Oncology, Division of Urology, University of Colorado Health Science Center and the University of Colorado Cancer Center, Denver, Colorado 80262, USA. david.crawford@uchsc.edu Epidemiology of prostate cancer. Urology. 2003 Dec 22;62(6 Suppl 1):3-12

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Kotake-Nara E, Kushiro M, Zhang H, Sugawara T, Miyashita K, Nagao A. Department of Bioresources Chemistry, Graduate School of Fisheries Science, Hokkaido University, 3-1-1 Hakodate 041-8611, Japan and. National Food Research Institute, 2-1-12 Kannondai, Tsukuba, Ibaraki 305-8642, Japan. Carotenoids Affect Proliferation of Human Prostate Cancer Cells. J Nutr 2001 Dec;131(12):3303-3306

Giovannucci E, Rimm EB, Liu Y, Stampfer MJ, Willett WC. Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. edward.giovannucci@channing.harvard.edu A prospective study of tomato products, lycopene, and prostate cancer risk. J Natl Cancer Inst 2002 Mar 6;94(5):391-8

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Grant WB - Calcium, lycopene, vitamin D and prostate cancer. Prostate 2000 Feb 15;42(3):243

Vogt TM, Mayne ST, Graubard BI, Swanson CA, Sowell AL, Schoenberg JB, Swanson GM, Greenberg RS, Hoover RN, Hayes RB, Ziegler RG. Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT, USA. vogtt@exchange.nih.gov Serum lycopene, other serum carotenoids, and risk of prostate cancer in US Blacks and Whites. Am J Epidemiol 2002 Jun 1;155(11):1023-32

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Giovannucci E - Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 1812 Longwood Avenue, Boston, MA 02115, USA. Edward.giovannucci@channing.harvard.edu A review of epidemiologic studies of tomatoes, lycopene, and prostate cancer. Exp Biol Med (Maywood) 2002 Nov;227(10):852-9

Minorsky PV- Department of Natural Sciences, Mercy College, Dobbs Ferry, NY 10522, USA. Lycopene and the prevention of prostate cancer: the love apple lives up to its name. Plant Physiol 2002 Nov;130(3):1077

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Kucuk O, Sarkar FH, Djuric Z, Sakr W, Pollak MN, Khachik F, Banerjee M, Bertram JS, Wood DP Jr. Division of Hematology and Oncology, 3990 John R, Barbara Ann Karmanos Cancer Institute, Wayne State University, 5 Hudson, Detroit, MI 48201, USA. kucuko@karmanos.org Effects of lycopene supplementation in patients with localized prostate cancer. Exp Biol Med (Maywood) 2002 Nov;227(10):881-5

Hadley CW, Miller EC, Schwartz SJ, Clinton SK. - Department of Food Science and Technology, Division of Hematology and Oncology, The James Cancer Hospital and Solove Research Institute, The Ohio State University, 320 W. 10th Avenue, Columbus, OH 43210, USA. Tomatoes, lycopene, and prostate cancer: progress and promise. Exp Biol Med (Maywood) 2002 Nov;227(10):869-80

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Hadley CW, Miller EC, Schwartz SJ, Clinton SK. - Department of Food Science and Technology, Division of Hematology and Oncology, The James Cancer Hospital and Solove Research Institute, The Ohio State University, 320 W. 10th Avenue, Columbus, OH 43210, USA. Tomatoes, lycopene, and prostate cancer: progress and promise. Exp Biol Med (Maywood) 2002 Nov;227(10):869-80

Fleshner N, Agarwal S, Rao V. University of Toronto, Ontario, Canada. Serum and tissue lycopene and biomarkers of oxidation in prostate cancer patients: a case control study. Prostate Cancer Prostatic Dis 2000 Dec;3(S1):S13

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Clinton SK, Emenhiser C, Schwartz SJ, Bostwick DG, Williams AW, Moore BJ, Erdman JW Jr Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115-6084, USA. cis-trans lycopene isomers, carotenoids, and retinol in the human prostate. Cancer Epidemiol Biomarkers Prev 1996 Oct;5(10):823-833

Miller EC, Giovannucci E, Erdman JW Jr, Bahnson R, Schwartz SJ, Clinton SK. Division of Hematology and Oncology, James Cancer Hospital, Solove Research Institute, Ohio State University Medical Center, Columbus, OH, USA. Tomato products, lycopene, and prostate cancer risk. Urol Clin North Am 2002 Feb;29(1):83-93

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Bowen P, Chen L, Stacewicz-Sapuntzakis M, Duncan C, Sharifi R, Ghosh L, Kim HS, Christov-Tzelkov K, van Breemen R - Department of Human Nutrition and Dietetics, m/c 517, University of Illinois, 1919 West Taylor Street, Chicago, IL 60612, USA. pbowen@uic.eduTomato sauce supplementation and prostate cancer: lycopene accumulation and modulation of biomarkers of carcinogenesis. Exp Biol Med (Maywood) 2002 Nov;227(10):886-93

Mills PK, Beeson WL, Phillips RL, Fraser GE - Department of Preventive Medicine, Loma Linda University School of Medicine, CA 92350. Cohort study of diet, lifestyle, and prostate cancer in Adventist men. Cancer 1989 Aug 1;64(3):598-604

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World Cancer Research Fund/American Institute for Cancer Research Food Nutrition and Prevention of Cancer: a global perspective. American Institute for Cancer Research, Washington DC, 1997

Hsing AW, Comstock GW, Abbey H, Polk BF - Department of Epidemiology, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, MD. Serologic precursors of cancer. Retinol, carotenoids, and tocopherol and risk of prostate cancer. J Natl Cancer Inst 1990 Jun 6;82(11):941-946

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Olson KB, Pienta KJ - Vitamins A and E: further clues for prostate cancer prevention. J Natl Cancer Inst 1998 Mar 18;90(6):414-415 - Comment on: J Natl Cancer Inst 1998 Mar 18;90(6):440-6

Nomura AM, Stemmermann GN, Lee J, Craft NE - Japan-Hawaii Cancer Study, Kuakini Medical Center, Honolulu, Hawaii 96817, USA. Serum micronutrients and prostate cancer in Japanese Americans in Hawaii. Cancer Epidemiol Biomarkers Prev 1997 Jul;6(7):487-491

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Giovannucci E, Rimm EB, Stampfer MJ, Colditz GA, Willett WC Department of Medicine, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115, USA.Diabetes mellitus and risk of prostate cancer (United States). Cancer Causes Control 1998 Jan;9(1):3-9

Rentzepis MJ; Newmark H; Lipkin M; Fair WR; Tomassi M; Huryk R; Heston WDWLycopene does not inhibit the growth of subcutaneously implanted LNCaP tumor cells in nude mice: Implications for chemoprevention. JOURNAL OF UROLOGY 1998, Vol 159, Iss 5, pp 13-13

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Yoshizawa K, Willett WC, Morris SJ, Stampfer MJ, Spiegelman D, Rimm EB, Giovannucci E Department of Nutrition, Harvard School of Public Health, Boston, MA, USA. Study of prediagnostic selenium level in toenails and the risk of advanced prostate cancer. J Natl Cancer Inst 1998 Aug 19;90(16):1219-1224 / Comment in: J Natl Cancer Inst 1998 Aug 19;90(16):1184-5

Hayes RB, Ziegler RG, Gridley G, Swanson C, Greenberg RS, Swanson GM, Schoenberg JB, Silverman DT, Brown LM, Pottern LM, Liff J, Schwartz AG, Fraumeni JF Jr, Hoover RN Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA. hayesr@epndce.nci.nih.gov Dietary factors and risks for prostate cancer among blacks and whites in the United States. Cancer Epidemiol Biomarkers Prev 1999 Jan;8(1):25-34

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Fleshner NE, Klotz LH - Department of Surgery, Toronto Sunnybrook Regional Cancer Center, University of Toronto, Canada. neil.fleshner@utoronto.ca Diet, androgens, oxidative stress and prostate cancer susceptibility. Cancer Metastasis Rev 1998-99;17(4):325-30

Grant WB - NASA Langley Research Center, Hampton, VA, USA. wbgrant@norfolk.infi.net An ecologic study of dietary links to prostate cancer. Altern Med Rev 1999 Jun;4(3):162-9

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Kumar NB, Besterman-Dahan K Department of Nutrition, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA. Nutrients in the Chemoprevention of Prostate Cancer: Current and Future Prospects. Cancer Control 1999 Nov;6(6):580-586

Kelloff GJ, Lieberman R, Steele VE, Boone CW, Lubet RA, Kopelovitch L, Malone WA, Crowell JA, Sigman CC National Cancer Institute, Division of Cancer Prevention, Chemoprevention Branch, Bethesda, MD 20892, USA. Chemoprevention of prostate cancer: concepts and strategies. Eur Urol 1999;35(5-6):342-50

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Thomas JA - Department of Pharmacology, University of Texas Health Science Center, San Antonio, USA. Diet, micronutrients, and the prostate gland. Nutr Rev 1999 Apr;57(4):95-103

Kristal AR, Cohen JH - Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. Invited commentary: tomatoes, lycopene, and prostate cancer. How strong is the evidence? Am J Epidemiol 2000 Jan 15;151(2):124-7; discussion 128-30

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Clinton SK - The dietary antioxidant network and prostate carcinoma. Cancer 1999 Nov 1;86(9):1629-31

Guttenplan JB, Chen M, Kosinska W, Thompson S, Zhao Z, Cohen LA Division of Basic Sciences/Biochemistry, New York University, Dental Center, 345 E. 24th St., New York, 10100, NY, USA Effects of a lycopene-rich diet on spontaneous and benzo[a]pyrene induced mutagenesis in porstate, colon, and lung of the lac Z mouse. Cancer Lett 2001 Mar 10;164(1):1-6

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Cristoni A, Di Pierro F, Bombardelli E - Scientific Department, Indena S.p.A., Viale Ortles 12, 20139, Milan, Italy Botanical derivatives for the prostate. Fitoterapia 2000 Aug;71 Suppl 1:S21-S28

Imaida K, Tamano S, Kato K, Ikeda Y, Asamoto M, Takahashi S, Nir Z, Murakoshi M, Nishino H, Shirai T 1st Department of Pathology Nagoya City University Medical School, 1-Kawasumi, Mizuho-ku, Nagoya 467-8601, Japan. imaida@med.nagoya-cu.ac.jp - Lack of chemopreventive effects of lycopene and curcumin on experimental rat prostate carcinogenesis. Carcinogenesis 2001 Mar;22(3):467-72

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Mucci LA, Tamimi R, Lagiou P, Trichopoulou A, Benetou V, Spanos E, Trichopoulos D. Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA, Department of Hygiene and Epidemiology, University of Athens Medical School, and Biomed International Diagnostic Center, Athens, Greece. Are dietary influences on the risk of prostate cancer mediated through the insulin-like growth factor system? BJU Int 2001 Jun;87(9):814-20

De la Taille, A.; Katz, A.; Vacherot, F.; Saint, F.; Salomon, L.; Cicco, A.; Abbou, C. C.; Chopin, D. K. Centre de Recherche chirurgicale, Service d'Urologie, H .pital Henri Mondor, 54, boulevard du Mar .chal de Lattre de Tassigny, F94100 Cr.teil. ad399@hotmail.com - Cancer of the prostate: influence of nutritional factors. Vitamins, antioxidants and trace elements  - Presse Med VOL. 30 NO. 11 2001 Mar 24 PP. 557-60

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Schroder, Fritz H.; Kranse, Ries; Dijk, Mathilde A.; Blom, Jan H. M.; van Kemenade, Monique; Dagnelie, Pieter C.; Tijburg, Lianne M.; Weststrate, Jan A.  - Rotterdam, Netherlands Dietary intervention in prostate cancer patients. Results of a randomized, double blind placebo controlled cross-over study.   Journal of Urology    VOL. 165  NO. 5 Supplement   May, 2001   PP. 65. June 02-07, 2001  Annual Meeting of the American Urological Association, Inc

Kucuk O, Sarkar FH, Sakr W, Djuric Z, Pollak MN, Khachik F, Li YW, Banerjee M, Grignon D, Bertram JS, Crissman JD, Pontes EJ, Wood DP Jr. Division of Hematology and Oncology, Wayne State University, and Barbara Ann Karmanos Cancer Institute, Detroit, MI 48201, USA. kucuko@karmanos.org Phase II randomized clinical trial of lycopene supplementation before radical prostatectomy. Cancer Epidemiol Biomarkers Prev 2001 Aug;10(8):861-868

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Kucuk O, Wood DP Jr. - Re: Response of hormone refractory prostate cancer to lycopene. J Urol 2002 Feb;167(2 Pt 1):651

van Breemen RB, Xu X, Viana MA, Chen L, Stacewicz-Sapuntzakis M, Duncan C, Bowen PE, Sharifi R. Department of Medicinal Chemistry and Pharmacognosy, General Clinical Research Center, and Department of Human Nutrition and Dietetics, University of Illinois at Chicago, Chicago, Illinois 60612, and Department of Urology, University of Illinois at Chicago and Westside Veterans Administration Hospital, Chicago, Illinois 60612. Liquid Chromatography-Mass Spectrometry of cis- and all-trans-Lycopene in Human Serum and Prostate Tissue after Dietary Supplementation with Tomato Sauce. J Agric Food Chem 2002 Apr 10;50(8):2214-2219

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Kotake-Nara E, Kim SJ, Kobori M, Miyashita K, Nagao A. Department of Bioresources Chemistry, Graduate School of Fisheries Science, Hokkaido University, Japan. Acyclo-retinoic acid induces apoptosis in human prostate cancer cells. Anticancer Res 2002 Mar-Apr;22(2A):689-95

McMILLAN DC, Talwar D, Sattar N, Underwood M, St J O'Reilly D, McARDLE C. University Department of Surgery, Glasgow The relationship between reduced vitamin antioxidant concentrations and the systemic inflammatory response in patients with common solid tumours. Clin Nutr 2002 Apr;21(2):161-164

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Schuurman AG, Goldbohm RA, Brants HA, van den Brandt PA. Department of Epidemiology, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands. A prospective cohort study on intake of retinol, vitamins C and E, and carotenoids and prostate cancer risk (Netherlands). Cancer Causes Control 2002 Aug;13(6):573-82

Van Gils CH, Bostick RM, Stern MC, Taylor JA. Molecular and Genetic Epidemiology Section, Laboratory of Molecular Carcinogenesis. National Institute of Environmental Health Sciences, NIH, Research Triangle Park, North Carolina 27709, USA. Differences in base excision repair capacity may modulate the effect of dietary antioxidant intake on prostate cancer risk: an example of polymorphisms in the XRCC1 gene.

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Cohen LA. American Health Foundation, Valhalla, New York 10595, USA. Lcohen@AHF.org Nutrition and prostate cancer: a review. Ann N Y Acad Sci 2002 Jun;963:148-55

Kucuk O. Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, Michigan 48201, USA. kucuko@karmanos.org Chemoprevention of prostate cancer.Cancer Metastasis Rev 2002;21(2):111-24

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Oh WK, Small EJ. Lank Center for Genitourinary Oncology, Department of Adult Oncology, Dana-Farber Cancer Institute and Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA. Complementary and alternative therapies in prostate cancer. Semin Oncol 2002 Dec;29(6):575-84

Gallagher RP, Kutynec CL. Clinical Professor, Department of Health Care and Epidemiology, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia. Diet, micronutrients and prostate cancer: a review of the evidence. Can J Urol. 1997 Jun;4(2 Supp 1):22-27

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Ansari MS, Gupta NP, Hemal AK. Department of Urology, All India Institute of Medical Sciences, New Delhi-110029, India. ansarimsa@hotmail.com Chemoprevention of carcinoma prostate: a review. Int Urol Nephrol. 2002;34(2):207-14

Clinton SK, Emenhiser C, Schwartz SJ, Bostwick DG, Williams AW, Moore BJ, Erdman JW Jr Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115-6084, USA. cis-trans lycopene isomers, carotenoids, and retinol in the human prostate. Cancer Epidemiol Biomarkers Prev 1996 Oct;5(10):823-833

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HEALTH PROFESSIONAL RESEARCH ABOUT CANCER RISK AND LYCOPENE In 1986 a survey of food intake was sent to 47894 health care professionals; follow-up surveys were sent in 1988, 1990, and 1992. The information was analyzed for trends in eating habits and various diseases, and consumption of several carotenoids was evaluated for a possible association with reduced risk of prostate cancer. Only lycopene was associated with a risk reduction (relative risk [RR] = 0.79, 95% confidence interval [CI] = 0.64-0.99). The foods associated with significant risk reduction were tomato sauce, pizza, and strawberries; the risk reduction for uncooked tomatoes was not significant. Tomato sauce and pizza are rich sources of lycopene, whereas strawberries, although red, do not contain lycopene. Tomato juice did not show an association, perhaps, the authors hypothesized, because of its low consumption. The association with strawberries was unexplained. The authors concluded that consumption of tomato-based foods may be linked to a reduced risk of prostate cancer.

ORGANIC LYCOPENE TO THE FOOD SUPPLEMENTS INDUSTRY BY PIERRE GROUP - THE PERFECT ANTIOXIDANT MADE IN ITALY

LYCOPENE SOURCES Lycopene is a carotenoid, a group of compounds present in many fresh fruits and vegetables. There are more than 750 types of carotenoids in nature; however, only 20 of these have been found in human blood and tissues. The carotenoid most often present in human blood is lycopene ,followed by b -carotene, lutein and zeaxanthin.

 RED RIPE TOMATOES THE MAIN SOURCE OF LYCOPENE and their derivatives are the main natural source of lycopene giving approximately 85% of all lycopene in the human body. The amount of lycopene in tomatoes depends the quality of fruit, the environment and cultivation procedures. Usually, the content of lycopene in red-ripe tomatoes is 30-80 mg/kg of fresh product, but it could be more than 150-300 mg/kg in some selected species obtained by traditional hybridization techniques.
PROPERTIES OF ORGANIC LYCOPENE the organic lycopene has a very strong antioxidant power, as antioxidant contrasts the destructive action of free radicals in the human body (which are seriously dangerous for the cells and tissues) protects and prevents against several diseases... SEE FULL INFORMATION

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